In the battles with infective diseases, warriors fight to protect their country – your body. They are the (un)known warriors, antibodies.
The specificity of an antibody is determined by its paratope (antigen-binding site), which is mainly made up of complementarity-determining regions (CDRs). There are 3 CDRs on each of the two polypeptide chains (heavy and light chains) of an antibody. The tertiary structures of these regions and the pharmacophore are of interest when we design an antibody to target a specific antigen. Here is a summary of models:
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