Module 9: Structure-based Drug Discovery

After four weeks of Mathematical Biology, I decided to switch to a chemistry course to explore something drastically different. In Structural Biology, modelling takes a different approach. In the previous module of Structural Biology, we had been exposed to the experimental methods and a tiny bit of physics behind solving for the crystal structures of … Continue reading Module 9: Structure-based Drug Discovery

Module 8: Mathematical Biology and Systems Medicine

This is a 4-week course on different families of mathematical modelling techniques, ranging from statistical modelling to Ordinary differential equations, from analytical to numerical techniques of solution. We began with systems analysis on sets of differential equations. It always amazes me as an engineer, who loves using numerical solvers to compute and visualise systems behaviour, … Continue reading Module 8: Mathematical Biology and Systems Medicine

Module 7: Bioinformatics and Statistical Genetics

Yet another course on applied statistics. We had lectures and practicals on Phylogenetics, Haplotype Phasing, Statistical alignment and population genetics (depicting how geographical migration evolves the genetic composition for the well-adapted species to prosper). Additionally, we spent indeed most of our time on an intense group project - we had only until Thursday to finish … Continue reading Module 7: Bioinformatics and Statistical Genetics

Module 6: Structural Biology

What is Structural Biology? It is a study of protein structures across the hierarchy, using experimental and computational techniques to recover the structures, hence using biophysics to extract information about their structural-functional relationship. In these two weeks, we have been exposed to a number of softwares used in structural biology, with Pymol being the obvious … Continue reading Module 6: Structural Biology

Module 4: Introduction to Experimental Biosciences

Experimentalists: we learnt your effort. The last two weeks have been packed with approximately 10 biological experiments, using different techniques. We started with extracting and sequencing our DNA using Sanger sequencing techniques, and drew a phylogenetic tree which proves that, yes I am a Chinese because my mitochondrial DNA shares the highest common features with … Continue reading Module 4: Introduction to Experimental Biosciences

Module 3: Scientific Computing

This module mainly uses a high-level language MATLAB to implement numerical solutions to basic models. The first week introduces the basics of MATLAB, from Ordinary differential equation (ODE) solvers to fast fourier transform, from command windows to GUI! I realised that the code for GUIs across different languages are fairly similar: firstly include the position … Continue reading Module 3: Scientific Computing