Wing Ki (Catherine) Wong

PhD in Bioinformatics, Scientist in Antibody Development

Epitope Prediction

Epitope is the antibody-binding region on the cognate antigen. Predicting what kind of antigen surfaces bind to a known antibody is useful in reverse engineering the antibody to target specific antigen.

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Antibody Modelling – Immunoinformatics

In the battles with infective diseases, warriors fight to protect their country – your body. They are the (un)known warriors, antibodies.

The specificity of an antibody is determined by its paratope (antigen-binding site), which is mainly made up of complementarity-determining regions (CDRs). There are 3 CDRs on each of the two polypeptide chains (heavy and light chains) of an antibody. The tertiary structures of these regions and the pharmacophore are of interest when we design an antibody to target a specific antigen. Here is a summary of models:

Paratope determination

Epitope determination

Computational Antibody Design

Feature extraction and clustering

Soft Tissue Mechanics – Constitutive Law

Constitutive laws describe material properties (strains and stresses). Since soft tissues are composed of fibres, which are not aligned, the angles at which the fibres are oriented have an impact on their mechanical properties. Here we consider the contributions from i) along the fibre $ \mathbf{f} $; ii) along the sheet $ \mathbf{s}$; and iii) in normal directions $ \mathbf{n} $.

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